Préime Exosomes and PDRN Booster Penrith

What These Products Are

Préime is a range made by EMA Aesthetics, an Irish company. Two products in the range are used at BLAAH, both applied to the skin during needling treatments rather than given as treatments in their own right.

This page exists because people ask what is actually going onto their skin, and the honest answer involves where these ingredients come from. That is worth reading before you book, not after.

Préime Pure Exosome Solution

Exosomes are nanoscale vesicles that cells release to carry signals to other cells, including signals involved in tissue repair. Applied to the skin, the idea is that they contribute to the signalling side of the repair process that needling has already started mechanically.

The exosomes in this product are derived from donated human umbilical cord blood, collected at birth through an accredited collection bank, screened, and processed under sterile conditions. The manufacturer states the source is traceable and that no cell culturing is used in extraction. We think you should know the origin of anything going onto broken skin, so we state it plainly rather than describing it only as a regenerative active.

It is used during dermal stamping and needling sessions, and can be applied after other treatments to support recovery.

Préime PDRN Booster Solution

PDRN stands for polydeoxyribonucleotide, a long-chain DNA fragment. The PDRN in this product is sourced from salmon trout milt, which shares a high proportion of its DNA sequence with human DNA. PDRN has an established history of use in wound care.

The Préime formulation is at 1% PDRN, chosen by the manufacturer as a concentration intended to support repair without provoking excess irritation. It also contains glutathione at 1%, non cross-linked hyaluronates for hydration and barrier support, and the peptides hexapeptide-8 and pentapeptide-4.

If you have a shellfish or marine allergy, say so before this product is used. It is a fish-derived ingredient and that matters more than it might sound on skin that has just been needled.

How We Use Them

Neither serum is a treatment you book on its own. They go onto the skin during and immediately after a needling treatment, while the micro-channels are still open and the skin is more permeable than usual. That window is the entire reason for applying them at that moment rather than at home.

At BLAAH they are used within dermal stamping and Dermapen 4 sessions, usually followed by LED light therapy. Which serum suits your skin, and whether either is worth adding at all, is decided at consultation.

Risks and What We Do Not Know

These serums are applied inside a treatment that deliberately breaks the skin barrier, so every risk of that treatment applies here too: redness, swelling, bruising, infection, cold sore reactivation, pigmentation change and, rarely, scarring. Applying any product into open micro-channels also carries a risk of irritation, contact dermatitis, allergic reaction and granuloma formation.

Being straight with you about the evidence: topical exosome and PDRN products are a newer area of cosmetic skincare than peels or needling, and the published independent evidence base is smaller than it is for treatments that have been in clinics for decades. Much of the available data comes from manufacturers. We use these serums because we think there is a reasonable rationale for them alongside needling, not because anyone can promise you a particular outcome from them.

Read our full risks and complications page, and raise anything relevant with your clinician at consultation.

Further Reading

Dr Niro Sivathasan (Cosmetic Physician, AHPRA MED0001769614) wrote the two press releases below for Préime, which give the manufacturer's account of each product. They are written for a professional audience and reflect the manufacturer's position rather than ours. Dr Sivathasan supports Préime in Australia and New Zealand, so read them with that in mind.

• Préime Pure Exosomes press release (PDF, 410 KB) January 2025. Written by Dr Niro Sivathasan.
• Préime PDRN Booster Solution press release (PDF, 405 KB) September 2025. Written by Dr Niro Sivathasan.

Frequently Asked Questions